ABSTRACT
Objective To evaluate the effect of Huatan-Tongfu decoction in the treatment of subarachnoid hemorrhage (SAH) with heat-phlegm and sthenic-fu syndrome.Methods The SAH patients met the inclusion criteria were randomly recruited into a control group and a treatment group, 41 patients in each group.The control group was treated with western conventional medicine and sustained administration of nimodipine injection;the treatment group was nasal feeding or oral taking Huatan-Tongfu decoction on the basis of the control group.Both groups were treated for 14 days.On respectively 3, 7, 14 days after treatment the level of subarachnoid hematocele was evaluated with modified Fisher gradehemorrhage, the degree of serum nitric oxide levels was detected with ELISA method, and the clinical efficacy was evaluated according to the neurological impairment score.Results The total effective rate of 3 d (46.3％ vs.36.6％, P=0.006), 7 d (58.5％ vs.43.9％, P=0.000), 14 d (73.2％ vs.58.5％, P=0.000) in the treatment group were better than the control group (P＜0.01).After treatment 7 d (22.93 ± 7.32 μmol/L vs.16.52 ± 5.79 μmol/L, P=0.034), 14 d (27.65 ± 5.06 μmol/L vs.19.54 ± 3.76 μmol/L, P=0.015) serum nitric oxide levels in the treatment group were higher than in the control group (P＜0.05).After treatment, the improved Fisher scoring (1.29 ± 0.23 vs.1.69 ± 0.38, t=5.766) in the treatment group was significantly lower than the control group (P＜0.01).Conclusion Huatan-Tongfu decoction can improve SAH with heat-phlegm and sthenic-fu syndrome, relieve neurological defect function, reduce levels of NO, and improve clinical efficacy.
ABSTRACT
Objective To study the influence of resolving phlegm and relaxing bowels decoction(Huatan Tongfu decoction)on plasma tissue type plasminogen activator(t-PA),plasminogen activator inhibitor(PAI)and homocysteine(Hcy)in patients with acute cerebral infarction. Methods With randomized and controlled clinical research,78 inpatients from 2010 to 2012 in Traditional Chinese Medicine(TCM)Department of Beijing Chaoyang Hospital,Capital Medical University were chosen,including 40 patients in observation group and 38 patients in control group. The patients in control and observation groups were treated by conventional treatment,and additionally the patients in observation group received Huatan Tongfu decoction(ingredients:Trichosanthis 30 g,Arisaema with bile 6 g,Magnolia bark 10 g,Fried rice sprout 15 g),and the rhubarb decoction was made alone,each 20 mL decoction containing crude drug 6 g. 1-4 days after the beginning of the study,the two decoctions were mixed,and the patients took the lukewarm mixture orally twice daily(once 1/2 the dosage);5-12 days after the start of the study, the patients took 200 mL lukewarm mixed decoction daily,being divided into 2 times to administer,and according to the patient defecation situation,the dosage of rhubarb decoction was adjusted individually,the therapeutic course being 12 days. The t-PA,PAI and Hcy were detected before treatment and on the 7th day after treatment. TCM syndrome scores(phlegm syndrome,fire-heat syndrome and sthenic-fu syndrome)were recorded before and on the 12th day after treatment,and the scores of National Institute of Health Stroke Scale(NIHSS)were recorded at the same time. Results Before treatment,the differences in t-PA,PAI,Hcy levels and NIHSS score and phlegm syndrome,fire-heat syndrome and sthenic-fu syndrome scores were not statistically significant;all the indicators improved significantly after treatment compared with those before treatment,and the changes in observation group were more remarkable〔t-PA(mg/L):13.03±2.15 vs. 12.95±2.16,PAI(mg/L):23.64±9.07 vs. 26.81±10.00, Hcy(μmol/L):9.13±1.15 vs. 11.52±3.17,phlegm syndrome:9.16±1.71 vs. 11.17±2.89,fire-heat syndrome:7.51±1.59 vs. 8.81±2.26, sthenic-fu syndrome:0.61±0.87 vs. 1.19±1.14, NIHSS score:5.70±3.16 vs. 5.90±2.97〕. Conclusion The mechanism of Huatan Tongfu decoction in treatment of patients with acute cerebral infarction accompanied by TCM syndromes of phlegm heat and sthenic-fu may be related to the reduction of plasma PAI and Hcy levels,protection of vascular endothelium and promotion of fibrinolysis,thereby the decoction can improve the clinical efficacy.